Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329649 | 1.00 | CTSK (0.43) | CTSKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9541732 | 0.87 | CTSK (0.45) | CTSKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8364058 | 0.87 | CTSK (0.45) | CTSKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9540332 | 0.80 | CTSK (0.47) | CTSKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL8491330 | 0.80 | CTSK (0.47) | CTSKNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5703708 | 0.80 | CTSK (0.57) | CTSKHPGDEPHX1ATMACHE | |
| SCHEMBL30314267 | 0.80 | CTSK (0.57) | CTSKHPGDEPHX1ATMACHE | |
| SCHEMBL12066889 | 0.80 | CTSK (0.36) | CTSKSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL30686731 | 0.80 | CTSK (0.36) | CTSKSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12066863 | 0.80 | CTSK (0.36) | CTSKSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783318-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0783318-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009836-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |