Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8325645 | 0.98 | THRB (0.45) | THRBMAPK8MAPTTP53KDM4E | |
| SCHEMBL8329797 | 0.91 | MAPK8 (0.44) | THRBMAPK8KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8327883 | 0.83 | MAPT (0.48) | THRBMAPTTP53KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8327246 | 0.83 | MAPT (0.47) | THRBMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL8559604 | 0.81 | MAPT (0.62) | THRBMAPTTP53KDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8561142 | 0.80 | MAPT (0.61) | THRBMAPTTP53KDM4ESMN1; SMN2 | |
| SCHEMBL8670121 | 0.80 | MAPT (0.49) | THRBMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL8563378 | 0.80 | PDE4B (0.59) | THRBMAPTTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL8328461 | 0.79 | MAPT (0.52) | THRBMAPTTP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL8561030 | 0.79 | MAPT (0.56) | THRBMAPTTP53KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |