Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329796 | 0.91 | THRB (0.46) | MAPK8KDM4EALDH1A1THRBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8325645 | 0.90 | THRB (0.45) | MAPK8KDM4EALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL8328843 | 0.83 | MEN1 (0.42) | EGFRERBB2KDM4EALDH1A1THRB | |
| SCHEMBL8330323 | 0.83 | MAPK8 (0.42) | MAPK8GRM5SMN1; SMN2PKM | |
| SCHEMBL8564146 | 0.79 | CSF1R (0.50) | EGFRERBB2THRBSMN1; SMN2MEN1 | |
| SCHEMBL8329674 | 0.79 | MAPT (0.43) | KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8323951 | 0.79 | MAPT (0.41) | EGFRERBB2KDM4EALDH1A1THRB | |
| SCHEMBL8329028 | 0.77 | THRB (0.38) | EGFRERBB2KDM4ETHRBMEN1 | |
| SCHEMBL8560369 | 0.77 | MAPT (0.44) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8330039 | 0.76 | MAPT (0.44) | MAPK8EGFRERBB2JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | claimed |