Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.62 |
| ▸ | GABRD | O14764 | 3/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.62 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.62 |
| ▸ | GABRE | P78334 | 3/20 | 0.62 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.62 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.62 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.62 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 8/20 | 0.44 |
| ▸ | CCND1 | P24385 | 8/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324889 | 0.84 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10574706 | 0.80 | GABRP (0.53) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6928418 | 0.77 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10389978 | 0.75 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783057 | 0.74 | GABRP (0.77) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20138118 | 0.73 | KMT2A (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2071194 | 0.73 | SMN1; SMN2 (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784192 | 0.72 | GABRP (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL13741229 | 0.72 | KDM4E (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6209806 | 0.72 | GABRP (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674631-B1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER (US) | 1999-12-08 | — | — | EP | disclosed |
| EP-0959074-A2 | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5968944-A | TREATING STRESS AND ANXIETY RELATED DISORDERS | PFIZER INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5958948-A | CORTICOTROPIN RELEASING FACTOR; THERAPY FOR STRESS | PFIZER, INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5705646-A | Substituted pyrazoles as CRF antagonists | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0674631-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013661-A1 | SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |