Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 3/20 | 0.55 |
| ▸ | GABRD | O14764 | 3/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.55 |
| ▸ | GABRE | P78334 | 3/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.55 |
| ▸ | CDK4 | P11802 | 12/20 | 0.41 |
| ▸ | CCND1 | P24385 | 12/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782945 | 0.88 | GABRP (0.74) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783268 | 0.84 | L3MBTL1 (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783144 | 0.83 | CCNE2 (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783057 | 0.83 | GABRP (0.77) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783431 | 0.80 | GABRP (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7580304 | 0.80 | CDK4 (0.40) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783009 | 0.79 | GABRP (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8784415 | 0.75 | CDK4 (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8329915 | 0.72 | GABRP (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8783368 | 0.72 | GABRB3 (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674625-B1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5668145-A | Amino-substituted pyrazoles having CRF antagonistic activity | PFIZER INC. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0674625-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994013644-A1 | AMINO-SUBSTITUTED PYRAZOLES HAVING CRF ANTAGONISTIC ACTIVITY | PFIZER INC. (US) | 1994-06-23 | — | — | WO | disclosed |