Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 12/20 | 0.53 |
| ▸ | HTR2A | P28223 | 12/20 | 0.53 |
| ▸ | HTR7 | P34969 | 12/20 | 0.53 |
| ▸ | HTR6 | P50406 | 12/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13806582 | 0.85 | OPRM1 (0.59) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL29622026 | 0.84 | BACE1 (0.68) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL318668 | 0.84 | BACE1 (0.68) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL12891008 | 0.83 | OPRM1 (0.58) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL16144189 | 0.83 | OPRM1 (0.58) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL1700315 | 0.83 | OPRM1 (0.58) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL18155836 | 0.83 | BACE1 (0.54) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL13610917 | 0.82 | OPRM1 (0.57) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL25317024 | 0.81 | HTR7 (0.62) | OPRM1OPRK1OPRL1BACE1HTR1A | |
| SCHEMBL4952229 | 0.81 | OPRL1 (0.60) | OPRM1OPRK1OPRL1BACE1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |