Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330089 | 0.89 | METAP2 (0.40) | METAP2METAP1ALDH1A1HTTMMP2 | |
| SCHEMBL8329853 | 0.84 | CTSK (0.37) | METAP2ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL8330172 | 0.82 | METAP2 (0.53) | METAP2METAP1ALDH1A1MMP2BMP1 | |
| SCHEMBL8331302 | 0.80 | METAP2 (0.51) | METAP2METAP1ALDH1A1MMP2BMP1 | |
| SCHEMBL28014935 | 0.78 | METAP1 (0.50) | METAP1SLC1A3SLC1A2SLC1A1CYP1A2 | |
| SCHEMBL11020999 | 0.77 | METAP2 (0.46) | METAP2MMP2BMP1ALOX5PPARG | |
| SCHEMBL11022081 | 0.77 | METAP2 (0.46) | METAP2MMP2BMP1ALOX5PPARG | |
| SCHEMBL11022554 | 0.77 | METAP2 (0.46) | METAP2MMP2BMP1ALOX5PPARG | |
| SCHEMBL8330092 | 0.77 | METAP2 (0.49) | METAP2METAP1ALDH1A1MMP2BMP1 | |
| SCHEMBL11023534 | 0.77 | METAP2 (0.46) | METAP2MMP2BMP1ALOX5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |