Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CCR1 | P32246 | 2/20 | 0.58 |
| ▸ | CCR5 | P51681 | 2/20 | 0.58 |
| ▸ | CCR8 | P51685 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13859958 | 0.85 | LMNA (0.72) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL29533982 | 0.83 | LMNA (0.69) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| Phenanthrene SCHEMBL16685315 | 0.83 | CCR1 (0.76) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL15106 | 0.83 | LMNA (0.69) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL262791 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL3045500 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL31141994 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL3193877 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL31286254 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 | |
| 1-Naphthoquinoline SCHEMBL6340901 | 0.81 | LMNA (0.67) | LMNACYP3A4KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915869-A1 | NOVEL TRICYCLIC N-CYANOIMINES USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998040376-A1 | PROCESS FOR PREPARING 1,4-DISUBSTITUTED PIPERIDINE COMPOUNDS | CILAG AG (CH) | 1998-09-17 | — | — | WO | disclosed |
| WO-1998004545-A1 | NOVEL TRICYCLIC N-CYANOIMINES USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |
| WO-1996031505-A1 | TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | PHARMACOPEIA, INC. (US) | 1996-10-10 | — | — | WO | disclosed |
| EP-0723540-A1 | TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES | SCHERING CORPORATION (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0535152-A1 | BIS-BENZO OR BENZOPYRIDO CYCLO HEPTA PIPERIDENE, PIPERIDYLIDENE AND PIPERAZINE COMPOUNDS AND COMPOSITIONS. | SCHERING CORP (US) | 1993-04-07 | — | — | EP | disclosed |
| EP-0471750-A1 | HETEROCYCLIC N-OXIDE DERIVATIVES OF SUBSTITUTED BENZO 5,6]CYCLOHEPTAPYRIDINES, COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1992-02-26 | — | — | EP | disclosed |
| WO-1990013548-A1 | HETEROCYCLIC N-OXIDE DERIVATIVES OF SUBSTITUTED BENZO[5,6]CYCLOHEPTAPYRIDINES, COMPOSITIONS AND METHODS OF USE | SCHERING CORPORATION (US) | 1990-11-15 | — | — | WO | disclosed |
| EP-0288640-A1 | 6,11-Dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridines and compositions and methods of use | SCHERING CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| US-4639457-A | CARDIOTONIC AGENTS | MERCK & CO., INC. (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0002512-B1 | IMINO-BRIDGED BENZOCYCLOHEPTAPYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF | MERCK & CO. INC. (US) | 1984-02-22 | — | — | EP | disclosed |
| US-4229455-A | MUSCLE RELAXANTS, TRANQUILIZERS | MERCK & CO., INC. (US) | 1980-10-21 | — | — | US | disclosed |
| EP-0002512-A1 | Imino-bridged benzocycloheptapyridines, process for their preparation and pharmaceutical composition thereof | MERCK & CO. INC. (US) | 1979-06-27 | — | — | EP | disclosed |