Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.45 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28163195 | 0.84 | FAAH (0.61) | FAAHMEN1KMT2AMAPK1PLA2G2C | |
| Citric Acid SCHEMBL323488 | 0.81 | FAAH (0.44) | FAAHMEN1KMT2AMAPK1PLA2G2C | |
| Citric Acid SCHEMBL9189183 | 0.81 | FAAH (0.44) | FAAHMEN1KMT2AMAPK1PLA2G2C | |
| Citric Acid SCHEMBL15348649 | 0.78 | FAAH (0.41) | FAAHMEN1KMT2AMAPK1PLA2G2C | |
| Citric Acid SCHEMBL23644590 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM | |
| Palmitic Acid SCHEMBL8514384 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM | |
| Myristic Acid SCHEMBL17054652 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM | |
| Stearic Acid SCHEMBL345023 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM | |
| Palmitic Acid SCHEMBL31391235 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM | |
| Stearic Acid SCHEMBL30375325 | 0.76 | GPR84 (0.65) | MEN1KMT2AALDH1A1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998048768-A9 | COMPOSITIONS FOR COSMETIC APPLICATIONS | MEDLOGIC GLOBAL CORP (US) | 1999-03-25 | — | — | WO | disclosed |