Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.77 |
| ▸ | NOS1 | P29475 | 9/20 | 0.74 |
| ▸ | NOS3 | P29474 | 9/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8192143 | 0.98 | NOS2 (0.75) | NOS2NOS1NOS3 | |
| SCHEMBL7049247 | 0.94 | NOS2 (0.77) | NOS2NOS1NOS3 | |
| Hydrochloric Acid SCHEMBL8193748 | 0.93 | NOS2 (0.74) | NOS2NOS1NOS3 | |
| SCHEMBL17721458 | 0.90 | NOS2 (0.79) | NOS2NOS1NOS3 | |
| SCHEMBL6279267 | 0.86 | NOS2 (0.71) | NOS2NOS1NOS3 | |
| SCHEMBL13040674 | 0.86 | NOS2 (0.97) | NOS2NOS1NOS3 | |
| SCHEMBL13040676 | 0.85 | NOS2 (1.00) | NOS2NOS1NOS3 | |
| SCHEMBL9313998 | 0.83 | NOS2 (0.54) | NOS2NOS1NOS3 | |
| SCHEMBL26538156 | 0.83 | NOS2 (1.00) | NOS2NOS1NOS3 | |
| SCHEMBL17721456 | 0.83 | NOS1 (0.67) | NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | claimed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |