SCHEMBL8330702

SCHEMBL8330702

CCOCCOCCNCCOCCN

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.41
RECQL P46063 2/20 0.41
TSHR P16473 2/20 0.34
ALDH1A1 P00352 4/20 0.33
CA12 O43570 3/20 0.33
CA6 P23280 3/20 0.33
CA7 P43166 3/20 0.33
CA9 Q16790 3/20 0.33
CA14 Q9ULX7 3/20 0.33
CA5B Q9Y2D0 3/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
THRB P10828 2/20 0.32
TDP1 Q9NUW8 3/20 0.32
CA2 P00918 3/20 0.32
LMNA P02545 2/20 0.32
CA3 P07451 2/20 0.32
CA4 P22748 2/20 0.32
CA5A P35218 2/20 0.32
CA1 P00915 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5933120 0.88 KDM4E (0.47) KDM4ERECQLTSHRALDH1A1MEN1
SCHEMBL10962985 0.88 KDM4E (0.47) KDM4ERECQLTSHRALDH1A1MEN1
SCHEMBL9437143 0.88 CA12 (0.42) KDM4ERECQLTSHRALDH1A1CA12
SCHEMBL7262297 0.88 CA12 (0.42) KDM4ERECQLTSHRALDH1A1CA12
SCHEMBL13520206 0.86 TSHR (0.38) KDM4ERECQLTSHRALDH1A1CA12
SCHEMBL13064013 0.86
SCHEMBL24181348 0.85 ALDH1A1 (0.43) TSHRALDH1A1THRB
SCHEMBL16329701 0.85 ALDH1A1 (0.43) TSHRALDH1A1THRB
SCHEMBL19977982 0.85 ALDH1A1 (0.43) TSHRALDH1A1THRB
SCHEMBL22806766 0.85 ALDH1A1 (0.43) TSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5972307-A ADMINISTERING TO HUMAN OR ANIMAL BODY AN EFFECTIVE AMOUNT OF A DIAGNOSTIC AGENT COMPRISES A METAL CHELATE OF A COMPOUND HAVING TWO MACROCYCLIC CHELANT GROUPS LINKED BY A BRIDGE CONTAINING ESTER OR AMIDE BOND NYCOMED SALUTAR, INC. (US) 1999-10-26 US disclosed
US-5650133-A CHELATING AGENTS USEFUL IN DIAGNOSTIC AND THERAPEUTIC COMPOSITIONS NYCOMED SALUTAR (US) 1997-07-22 US disclosed