Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330920 | 0.94 | LMNA (0.53) | PPARGLMNAPPARASMN1; SMN2MAPT | |
| SCHEMBL8331884 | 0.91 | SMN1; SMN2 (0.48) | PPARGLMNAPPARASMN1; SMN2MAPT | |
| SCHEMBL3574336 | 0.87 | LMNA (0.47) | PPARGLMNAPPARASMN1; SMN2MAPT | |
| SCHEMBL8331880 | 0.84 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL8329553 | 0.81 | L3MBTL1 (0.51) | PPARGLMNAPPARASMN1; SMN2MAPT | |
| SCHEMBL8330509 | 0.79 | TNKS2 (0.42) | ALDH1A1 | |
| SCHEMBL28279430 | 0.78 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL7376682 | 0.78 | LMNA (0.55) | PPARGLMNAPPARASMN1; SMN2MAPT | |
| SCHEMBL7437838 | 0.77 | TDP1 (0.52) | LMNASMN1; SMN2MAPTTDP1CTSK | |
| SCHEMBL11204299 | 0.77 | TDP1 (0.59) | PPARGLMNAPPARASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |