Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.42 |
| ▸ | RARG | P13631 | 9/20 | 0.42 |
| ▸ | RARA | P10276 | 8/20 | 0.42 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331565 | 0.97 | RARB (0.42) | RARBRARGRARARXRACYP3A4 | |
| SCHEMBL8331366 | 0.81 | RXRA (0.40) | RARBRARGRARARXRA | |
| SCHEMBL8329471 | 0.78 | RXRA (0.40) | RARBRARGRARARXRA | |
| SCHEMBL8333554 | 0.74 | RARA (0.41) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8328191 | 0.74 | RARB (0.41) | RARBRARGRARA | |
| SCHEMBL7571992 | 0.73 | RARB (0.41) | RARBRARGRARARXRACYP3A4 | |
| SCHEMBL8332981 | 0.71 | RARB (0.41) | RARBRARGRARA | |
| SCHEMBL8332049 | 0.71 | RARA (0.41) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8293245 | 0.71 | RARA (0.47) | RARBRARGRARARXRACYP3A4 | |
| SCHEMBL9188112 | 0.69 | RARA (0.49) | RARBRARGRARARXRACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5917082-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN SALES, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5817836-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-10-06 | — | — | US | disclosed |
| US-5780647-A | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-07-14 | — | — | US | disclosed |
| US-5675033-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |