Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | RARA | P10276 | 6/20 | 0.44 |
| ▸ | RARB | P10826 | 5/20 | 0.44 |
| ▸ | RARG | P13631 | 5/20 | 0.44 |
| ▸ | RXRA | P19793 | 4/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998188 | 0.83 | CYP26A1 (0.49) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL2246604 | 0.83 | CYP26A1 (0.51) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL8773454 | 0.80 | CYP26A1 (0.49) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL8330612 | 0.80 | RARA (0.58) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL2243072 | 0.77 | CYP26A1 (0.48) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL12348759 | 0.77 | CYP26A1 (0.48) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL6146899 | 0.75 | CYP26A1 (0.69) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL10959891 | 0.74 | CYP26A1 (0.46) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL8698629 | 0.74 | RARA (0.55) | CYP26A1CYP26B1RARARARBRARG | |
| SCHEMBL8328531 | 0.73 | RARA (0.44) | CYP26A1CYP26B1RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5917082-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN SALES, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5886005-A | 4-Aza-19-norandrostane derivatives | MERCK & CO., INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5817836-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-10-06 | — | — | US | disclosed |
| US-5780647-A | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-07-14 | — | — | US | disclosed |
| EP-0804205-A4 | 4-AZA-19-NORANDROSTANE DERIVATIVES | MERCK & CO INC (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0804205-A1 | 4-AZA-19-NORANDROSTANE DERIVATIVES | Merck & Co., Inc. (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5675033-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |
| WO-1996022100-A1 | 4-AZA-19-NORANDROSTANE DERIVATIVES | MERCK & CO., INC. (US) | 1996-07-25 | — | — | WO | disclosed |