Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.58 |
| ▸ | RARB | P10826 | 3/20 | 0.58 |
| ▸ | RARG | P13631 | 3/20 | 0.58 |
| ▸ | RXRA | P19793 | 8/20 | 0.49 |
| ▸ | RXRB | P28702 | 5/20 | 0.49 |
| ▸ | RXRG | P48443 | 4/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 7/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8332964 | 0.80 | CYP26A1 (0.46) | RARARARBRARGRXRARXRB | |
| SCHEMBL8328531 | 0.80 | RARA (0.44) | RARARARBRARGRXRARXRB | |
| SCHEMBL8559846 | 0.80 | RARA (0.40) | RARARARBRARGRXRARXRB | |
| SCHEMBL4440994 | 0.80 | RARA (0.56) | RARARARBRARGRXRARXRB | |
| SCHEMBL2095481 | 0.79 | RXRA (0.57) | RARARARBRARGRXRARXRB | |
| SCHEMBL11648365 | 0.78 | RARA (0.51) | RARARARBRARGRXRARXRB | |
| SCHEMBL6431035 | 0.78 | RARA (0.51) | RARARARBRARGRXRARXRB | |
| SCHEMBL4365965 | 0.76 | CYP26B1 (0.55) | RARARARBRARGRXRARXRB | |
| SCHEMBL14286073 | 0.75 | RXRA (0.53) | RARARARBRARGRXRARXRB | |
| SCHEMBL8328559 | 0.75 | RXRA (0.47) | RARARARBRARGRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5917082-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN SALES, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5817836-A | 2,4-pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-10-06 | — | — | US | disclosed |
| US-5780647-A | 2,4-Pentadienoic acid derivatives having retinoid-like biological activity | ALLERGAN (US) | 1998-07-14 | — | — | US | disclosed |
| US-5675033-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |