Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556091 | 0.87 | SIGMAR1 (0.51) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6719922 | 0.84 | SIGMAR1 (0.57) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL14330966 | 0.77 | TP53 (0.41) | TP53LMNAMAPT | |
| SCHEMBL8334064 | 0.77 | SIGMAR1 (0.45) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8194426 | 0.75 | SIGMAR1 (0.75) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8194423 | 0.75 | SIGMAR1 (0.43) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6720863 | 0.75 | GAA (0.41) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL8399203 | 0.74 | SIGMAR1 (0.49) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6716755 | 0.74 | SIGMAR1 (0.42) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8332943 | 0.73 | SIGMAR1 (0.52) | SIGMAR1TP53CYP2D6TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999002145-A1 | COMBINATION DRUG THERAPIES COMPRISING AMINOGLYCOSIDE ANTIBIOTICS AND N,N'-DISUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-01-21 | — | — | WO | claimed |