Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 20/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337461 | 0.86 | RECQL (0.39) | SIGMAR1TP53MEN1LMNAKMT2A | |
| SCHEMBL5556091 | 0.85 | SIGMAR1 (0.51) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8843004 | 0.85 | SIGMAR1 (0.64) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8332943 | 0.85 | SIGMAR1 (0.52) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8397401 | 0.83 | SIGMAR1 (0.54) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL10404786 | 0.82 | LMNA (0.40) | SIGMAR1MEN1LMNAMAPTKMT2A | |
| SCHEMBL27500780 | 0.80 | SIGMAR1 (0.48) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL27498292 | 0.80 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL27527832 | 0.80 | SIGMAR1 (0.55) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL8741327 | 0.77 | SIGMAR1 (0.49) | SIGMAR1TP53CYP2D6TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918460-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998004131-A1 | METHODS OF TREATMENT OF EYE TRAUMA AND DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1998-02-05 | — | — | WO | disclosed |