Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214742 | 0.89 | ALDH1A1 (0.67) | ALDH1A1HPGDTSHRPOLBHTT | |
| SCHEMBL27272914 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HPGDTSHRPOLBHTT | |
| SCHEMBL876142 | 0.83 | ALDH1A1 (0.58) | ALDH1A1HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL181041 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDTSHRPOLBHTT | |
| SCHEMBL3202573 | 0.82 | ALDH1A1 (0.72) | ALDH1A1HPGDTSHRHTTSIGMAR1 | |
| SCHEMBL7259696 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HPGDTSHRPOLBHTT | |
| SCHEMBL4634132 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HPGDTSHRPOLBL3MBTL1 | |
| SCHEMBL8764227 | 0.77 | MEN1 (0.52) | ALDH1A1HPGDTSHRHTTL3MBTL1 | |
| SCHEMBL407210 | 0.76 | ALDH1A1 (0.64) | ALDH1A1HPGDTSHRPOLBHTT | |
| SCHEMBL3237701 | 0.76 | ALDH1A1 (0.55) | ALDH1A1HPGDTSHRHTTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925647-A | TREATMENT OF INSULIN NON-INSULIN DEPENDENT DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-07-20 | — | — | US | disclosed |
| US-5917052-A | Hypoglycemic agent from cryptolepis | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5753790-A | ANTIDIABETIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1998-05-19 | — | — | US | disclosed |
| US-5681958-A | TREATMENT OF DIABETES | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| US-5629319-A | QUINDOLINE ALKALOIDS | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-05-13 | — | — | US | disclosed |
| US-5628999-A | PLANT EXTRACTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1997-05-13 | — | — | US | disclosed |