Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017658 | 0.89 | HDAC1 (0.47) | PRSS1HDAC1HDAC3NCOR2 | |
| SCHEMBL7088249 | 0.82 | SMN1; SMN2 (0.44) | PRSS1HDAC1HDAC3HDAC6 | |
| SCHEMBL23963004 | 0.82 | HDAC1 (0.50) | PRSS1HDAC1HDAC3ALDH1A1NCOR2 | |
| SCHEMBL8255720 | 0.81 | HDAC1 (0.44) | PRSS1HDAC1HDAC3ALDH1A1KDM4E | |
| SCHEMBL4063331 | 0.80 | HDAC1 (0.52) | PRSS1HDAC1HDAC3ALDH1A1NCOR2 | |
| SCHEMBL1464213 | 0.79 | PRSS1 (0.49) | PRSS1HDAC1HDAC3CYP19A1HDAC6 | |
| SCHEMBL30516497 | 0.79 | HDAC6 (0.63) | PRSS1CYP19A1HDAC6ALDH1A1KDM4E | |
| SCHEMBL30516524 | 0.79 | PRSS1 (0.49) | PRSS1CYP19A1HDAC6ALDH1A1HSD17B10 | |
| SCHEMBL31442001 | 0.79 | PRSS1 (0.49) | PRSS1CYP19A1HDAC6ALDH1A1KDM4E | |
| SCHEMBL6248663 | 0.79 | HDAC6 (0.63) | PRSS1CYP19A1HDAC6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |