Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 9/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 7/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 6/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MYLK | Q15746 | 1/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323648 | 0.83 | KIF11 (0.48) | TMPRSS4P2RX1P2RX4P2RX7KIF11 | |
| SCHEMBL330660 | 0.81 | ACMSD (0.66) | KIF11SLC6A2P2RY14MEN1KMT2A | |
| SCHEMBL28710614 | 0.81 | ACMSD (0.66) | MCL1KDM4E | |
| SCHEMBL8336975 | 0.80 | CHUK (0.66) | TMPRSS4P2RX1P2RX4P2RX7KIF11 | |
| SCHEMBL5927653 | 0.80 | KIF11 (0.48) | TMPRSS4P2RX1P2RX4P2RX7NPC1 | |
| SCHEMBL5428269 | 0.79 | HDAC6 (0.56) | NPC1CRHBPRAB9ACRHR2KIF11 | |
| SCHEMBL4829529 | 0.74 | CDK2 (0.53) | KDR | |
| SCHEMBL5927052 | 0.74 | TACR3 (0.44) | TMPRSS4P2RX1P2RX4P2RX7NPC1 | |
| SCHEMBL6850836 | 0.74 | GAA (0.61) | NPC1CRHBPRAB9ACRHR2KDM4E | |
| SCHEMBL327248 | 0.73 | GAA (0.60) | TMPRSS4P2RX1P2RX4P2RX7KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |