Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336291 | 0.92 | MAPT (0.43) | MAPTALDH1A1CNR2KDM4EMEN1 | |
| SCHEMBL8340604 | 0.92 | MAPT (0.43) | MAPTALDH1A1LMNAHSD17B10CNR2 | |
| SCHEMBL8334344 | 0.90 | MAPT (0.38) | MAPTALDH1A1LMNAHSD17B10CNR2 | |
| SCHEMBL8336809 | 0.89 | CNR2 (0.47) | MAPTALDH1A1HSD17B10CNR2KDM4E | |
| SCHEMBL8337435 | 0.88 | MAPT (0.46) | MAPTALDH1A1LMNAHSD17B10CNR2 | |
| SCHEMBL8334430 | 0.86 | CNR2 (0.41) | MAPTALDH1A1CNR2KDM4EMEN1 | |
| SCHEMBL8340660 | 0.84 | MAPT (0.45) | MAPTALDH1A1LMNACNR2KDM4E | |
| SCHEMBL8340813 | 0.82 | TUBB4A (0.40) | MAPTALDH1A1CNR2KDM4EMEN1 | |
| SCHEMBL8336438 | 0.81 | CNR2 (0.46) | MAPTALDH1A1HSD17B10CNR2KDM4E | |
| SCHEMBL8340639 | 0.79 | CNR2 (0.41) | MAPTCNR2KDM4EMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5948796-A | OSTEOPOROSIS, CANCER, CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |