Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
| ▸ | MC5R | P33032 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12956108 | 0.91 | TAS2R14 (0.36) | TAS2R14KEAP1NFE2L2LMNAMAPT | |
| SCHEMBL1037038 | 0.81 | HCRTR2 (0.57) | TACR1HCRTR2KEAP1NFE2L2MAPT | |
| SCHEMBL1040591 | 0.77 | HCRTR2 (0.46) | TACR1HCRTR2TAS2R14KEAP1NFE2L2 | |
| SCHEMBL1039701 | 0.75 | KEAP1 (0.41) | TACR1HCRTR2TAS2R14KEAP1NFE2L2 | |
| SCHEMBL1038614 | 0.74 | HCRTR2 (0.43) | TACR1HCRTR2TAS2R14TRPM8KEAP1 | |
| SCHEMBL1040843 | 0.72 | HCRTR2 (0.53) | HCRTR2TAS2R14KEAP1NFE2L2LMNA | |
| SCHEMBL1040093 | 0.69 | HCRTR2 (0.54) | HCRTR2MAPTALDH1A1 | |
| SCHEMBL1038697 | 0.68 | HCRTR2 (0.56) | HCRTR2KEAP1NFE2L2LMNAMAPT | |
| SCHEMBL1041009 | 0.68 | HCRTR2 (0.56) | HCRTR2KEAP1NFE2L2LMNAMAPT | |
| SCHEMBL1035896 | 0.67 | KEAP1 (0.44) | HCRTR2TAS2R14KEAP1NFE2L2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554239-B1 | SULFONYLAMINO-ACETIC ACID DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-01-26 | — | — | EP | disclosed |
| WO-2004033418-A2 | SULFONYLAMINO-ACETIC DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2004-04-22 | — | — | WO | disclosed |