Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14769156 | 0.79 | KMT2A (0.45) | KMT2ATDP1CYP1A2HTTKDM4E | |
| SCHEMBL12800844 | 0.79 | KMT2A (0.83) | KMT2ATDP1CYP1A2PIK3CDHTT | |
| SCHEMBL8283794 | 0.79 | KMT2A (0.43) | KMT2ATDP1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL25255316 | 0.77 | CYP1A2 (0.50) | KMT2ATDP1CYP1A2PIK3CDHRH3 | |
| SCHEMBL8335750 | 0.77 | F2 (0.46) | KMT2ATDP1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL8348142 | 0.77 | CYP1A2 (0.50) | KMT2ATDP1CYP1A2PIK3CDHRH3 | |
| SCHEMBL26631959 | 0.73 | KMT2A (0.43) | KMT2AHTTHSD17B10 | |
| SCHEMBL8435233 | 0.73 | ALDH1A1 (0.50) | KMT2ATDP1CYP1A2PIK3CDHTT | |
| SCHEMBL14407779 | 0.72 | CYP1A2 (0.77) | KMT2ATDP1CYP1A2PIK3CDHRH3 | |
| SCHEMBL37407 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018465-A9 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-09-15 | — | — | WO | disclosed |
| WO-2004018465-A2 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |