SCHEMBL8335369

SCHEMBL8335369

O=C=Nc1c(F)cc(Cl)c2nc(Cl)sc12

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8688493 0.86 MAPK1 (0.40) MAPK1TDP1ALDH1A1
SCHEMBL8333331 0.86 MAPK1 (0.32) MAPK1TDP1
SCHEMBL9149540 0.85 ALDH1A1 (0.31) ALDH1A1
SCHEMBL8308802 0.82
SCHEMBL8333397 0.82 KDR (0.32)
SCHEMBL8333778 0.78
SCHEMBL8310259 0.75
SCHEMBL27382701 0.75 CCNE1 (0.32)
SCHEMBL9148367 0.71 SMN1; SMN2 (0.38) ALDH1A1
Hydrochloric Acid SCHEMBL9147162 0.70 SMN1; SMN2 (0.37) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5888940-A DESICCATING PLANTS BASF AKTIENGESELLSCHAFT (DE) 1999-03-30 US disclosed
EP-0862569-A1 SUBSTITUTED BENZOTHIAZOLS WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1998-09-09 EP disclosed
WO-1997008171-A1 SUBSTITUTED BENZOTHIAZOLS WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1997-03-06 WO disclosed
US-5424443-A Substituted benzothiazole derivatives, their preparation and use as herbicides SCHERING AKTIENGESELLSCHAFT (DE) 1995-06-13 US disclosed
EP-0583353-A1 SUBSTITUTED BENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS HERBICIDES SCHERING AKTIENGESELLSCHAFT (DE) 1994-02-23 EP disclosed
WO-1992020675-A1 SUBSTITUTED BENZOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND USE AS HERBICIDES SCHERING AKTIENGESELLSCHAFT (DE) 1992-11-26 WO disclosed