Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339931 | 0.92 | TDP1 (0.48) | LMNATDP1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL8335900 | 0.85 | TDP1 (0.46) | LMNAPKMTDP1SMN1; SMN2RAB9A | |
| SCHEMBL8340529 | 0.68 | TDP1 (0.44) | LMNATDP1GAACNR2SMN1; SMN2 | |
| SCHEMBL8335999 | 0.67 | TDP1 (0.51) | LMNATDP1CNR2SMN1; SMN2NPC1 | |
| SCHEMBL169824 | 0.67 | TDP1 (0.76) | LMNATDP1GAASMN1; SMN2NPC1 | |
| SCHEMBL8352827 | 0.67 | SMN1; SMN2 (0.60) | LMNAALPIPKMTDP1CNR2 | |
| SCHEMBL8336596 | 0.67 | TDP1 (0.53) | LMNATDP1CNR2SMN1; SMN2NPC1 | |
| SCHEMBL8340007 | 0.66 | TDP1 (0.49) | LMNATDP1CNR2SMN1; SMN2RAB9A | |
| SCHEMBL7916079 | 0.65 | SMN1; SMN2 (0.57) | LMNAALPIPKMTDP1CNR2 | |
| SCHEMBL8340133 | 0.64 | TDP1 (0.37) | LMNAPKMTDP1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |