Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336185 | 0.94 | TDP1 (0.38) | TDP1UBE2NSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8338913 | 0.91 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1CYP2C19KMT2ACYP1A2 | |
| SCHEMBL8335504 | 0.79 | TDP1 (0.35) | TDP1UBE2NSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8339931 | 0.72 | TDP1 (0.48) | TDP1SMN1; SMN2ALDH1A1CYP2C19HTT | |
| SCHEMBL8339200 | 0.69 | DRD3 (0.36) | SMN1; SMN2ALDH1A1POLBCYP2C19KDM4E | |
| SCHEMBL8335900 | 0.69 | TDP1 (0.46) | TDP1SMN1; SMN2ALDH1A1CYP2C19HTT | |
| SCHEMBL169824 | 0.64 | TDP1 (0.76) | TDP1SMN1; SMN2ALDH1A1CYP2C19GAA | |
| SCHEMBL8340223 | 0.64 | MMP1 (0.34) | TDP1ALDH1A1GAAHTTKDM4E | |
| SCHEMBL8335999 | 0.63 | TDP1 (0.51) | TDP1SMN1; SMN2ALDH1A1CYP2C19HTT | |
| SCHEMBL8336596 | 0.62 | TDP1 (0.53) | TDP1SMN1; SMN2ALDH1A1CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |