Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | APP | P05067 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337333 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL6965868 | 0.86 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL6965864 | 0.86 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL6972867 | 0.85 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDMAPTGAA | |
| SCHEMBL6961279 | 0.83 | KDM4E (0.81) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL6961283 | 0.83 | KDM4E (0.81) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL2451702 | 0.80 | APP (0.65) | ALDH1A1KDM4EHPGDAPPSMN1; SMN2 | |
| SCHEMBL2451704 | 0.80 | APP (0.65) | ALDH1A1KDM4EHPGDAPPSMN1; SMN2 | |
| SCHEMBL6583463 | 0.80 | PTGS1 (0.44) | ALDH1A1KDM4EHPGDMAPTAPP | |
| SCHEMBL6583457 | 0.80 | PTGS1 (0.44) | ALDH1A1KDM4EHPGDMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |