Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.81 |
| ▸ | HPGD | P15428 | 2/20 | 0.81 |
| ▸ | FDPS | P14324 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | BCHE | P06276 | 3/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA5A | P35218 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961279 | 1.00 | KDM4E (0.81) | KDM4EALDH1A1MAPTHPGDFDPS | |
| SCHEMBL6965864 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPTHPGDAPP | |
| SCHEMBL8337336 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPTHPGDAPP | |
| SCHEMBL6965868 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPTHPGDAPP | |
| SCHEMBL8337333 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1MAPTHPGDAPP | |
| SCHEMBL6972867 | 0.82 | ALDH1A1 (0.64) | KDM4EALDH1A1MAPTHPGDFDPS | |
| SCHEMBL5685437 | 0.82 | FDPS (0.74) | KDM4EALDH1A1HPGDFDPSTTR | |
| SCHEMBL5685435 | 0.82 | FDPS (0.74) | KDM4EALDH1A1HPGDFDPSTTR | |
| SCHEMBL6584017 | 0.82 | FDPS (0.59) | KDM4EALDH1A1MAPTHPGDFDPS | |
| SCHEMBL6584022 | 0.82 | FDPS (0.59) | KDM4EALDH1A1MAPTHPGDFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783496-B9 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-0783496-B1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |