Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 7/20 | 0.60 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881373 | 0.92 | MMP12 (0.55) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6663858 | 0.88 | MMP12 (0.59) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6462719 | 0.86 | MMP12 (0.64) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6456507 | 0.85 | MMP12 (0.72) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6458023 | 0.85 | MMP12 (0.56) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6874175 | 0.84 | MMP12 (0.57) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6881497 | 0.83 | DHODH (0.48) | MMP12 | |
| SCHEMBL6450465 | 0.83 | MMP12 (0.62) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6881245 | 0.83 | MMP12 (0.57) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6456642 | 0.81 | MMP12 (0.56) | MMP12MMP13MAPK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |