Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 7/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337355 | 0.92 | MMP12 (0.60) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6881245 | 0.89 | MMP12 (0.57) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6663858 | 0.86 | MMP12 (0.59) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6462719 | 0.84 | MMP12 (0.64) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6456507 | 0.84 | MMP12 (0.72) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6458023 | 0.83 | MMP12 (0.56) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6874175 | 0.82 | MMP12 (0.57) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6456642 | 0.82 | MMP12 (0.56) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6461952 | 0.82 | MMP12 (0.55) | MMP12MMP13MAPK1ROCK2ROCK1 | |
| SCHEMBL6450465 | 0.81 | MMP12 (0.62) | MMP12MMP13MAPK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | claimed |
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | MMP12 7/4885MMP13 2/4885MAPK1 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.