Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337635 | 0.99 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL8337867 | 0.99 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL5927145 | 0.87 | PTGDR2 (0.47) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL4723723 | 0.83 | LRRK2 (0.58) | LMNAKDM4EPOLBPARP1 | |
| SCHEMBL4970659 | 0.83 | LMNA (0.66) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL8337873 | 0.83 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DSIRT2 | |
| SCHEMBL3993071 | 0.83 | PTGDR2 (0.48) | PTGDR2MEN1KMT2ALMNAHTR2B | |
| SCHEMBL16997486 | 0.79 | PTGDR2 (0.48) | PTGDR2MEN1KMT2ALMNANR1I2 | |
| SCHEMBL8337852 | 0.78 | PTGES (0.59) | SIRT2PARP1 | |
| SCHEMBL7119572 | 0.78 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014844-A2 | ARYL AND HETEROARYL COMPOUNDS AND METHODS TO MODULATE COAGULATION | TRANSTECH PHARMA, INC. (US) | 2004-02-19 | — | — | WO | disclosed |