SCHEMBL8337674

SCHEMBL8337674

ON=C(c1ccc(F)cc1F)C1CCOCC1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CES2 O00748 2/20 0.40
CES1 P23141 2/20 0.40
HDAC1 Q13547 2/20 0.36
HDAC2 Q92769 2/20 0.36
HDAC3 O15379 1/20 0.36
OPRL1 P41146 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
CNR1 P21554 1/20 0.34
MAPK8 P45983 1/20 0.33
MAPK10 P53779 1/20 0.33
MAPK14 Q16539 1/20 0.33
MAPK1 P28482 1/20 0.33
CNR2 P34972 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8071415 0.83 L3MBTL1 (0.42) L3MBTL1CES2CES1
SCHEMBL1833474 0.83 L3MBTL1 (0.42) L3MBTL1CES2CES1
SCHEMBL30640891 0.83 L3MBTL1 (0.42) L3MBTL1CES2CES1
SCHEMBL4718081 0.83 L3MBTL1 (0.42) L3MBTL1CES2CES1
Hydrochloric Acid SCHEMBL1833471 0.82 L3MBTL1 (0.41) L3MBTL1CES2CES1
Hydrochloric Acid SCHEMBL1833472 0.82 L3MBTL1 (0.41) L3MBTL1CES2CES1
SCHEMBL28026688 0.81 L3MBTL1 (0.50) L3MBTL1MEN1KMT2ACES2CES1
SCHEMBL5021047 0.79 ACKR3 (0.48) L3MBTL1MEN1KMT2ACES2CES1
SCHEMBL14542094 0.79 L3MBTL1 (0.40) L3MBTL1MEN1KMT2ACES2CES1
SCHEMBL13390925 0.79 ACKR3 (0.48) L3MBTL1MEN1KMT2ACES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080262227-A1 PROCESS FOR MAKING RISPERIDONE AND INTERMEDIATES THEREFOR SLANINA PAVEL 2008-10-23 US disclosed
US-20080262227-A1 PROCESS FOR MAKING RISPERIDONE AND INTERMEDIATES THEREFOR SLANINA PAVEL 2008-10-23 US disclosed
US-7405298-B2 Process for making risperidone and intermediates therefor SYNTHON IP INC. (US) 2008-07-29 US disclosed
US-7405298-B2 Process for making risperidone and intermediates therefor SYNTHON IP INC. (US) 2008-07-29 US disclosed
WO-2004043923-A1 PROCESS FOR MAKING RISPERIDONE AND INTERMEDIATES THEREFOR SYNTHON B.V. (NL) 2004-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080262227-A1 PROCESS FOR MAKING RISPERIDONE AND INTERMEDIATES THEREFOR FAR1, HSD17B11, CYP4Z1 L3MBTL1 3715/4885MEN1 4076/4885KMT2A 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.