SCHEMBL6675124

SCHEMBL6675124

CN1CCC(Oc2cc(NS(=O)(=O)c3cccc4c3CCCC4)ccc2C(F)(F)F)C1

nearest known ligand 0.65

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.65
BRD4 O60885 1/20 0.38
METAP2 P50579 1/20 0.38
HSD11B1 P28845 1/20 0.38
HSD17B2 P37059 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8331713 1.00 UTS2R (0.65) UTS2RBRD4METAP2HSD11B1HSD17B2
SCHEMBL6686658 0.98 UTS2R (0.65) UTS2RBRD4
SCHEMBL8342929 0.85 UTS2R (0.73) UTS2RBRD4
SCHEMBL8337677 0.84 UTS2R (0.67) UTS2R
SCHEMBL6676194 0.83 UTS2R (0.68) UTS2R
SCHEMBL6676187 0.83 UTS2R (0.68) UTS2R
SCHEMBL6677197 0.83 UTS2R (0.63) UTS2R
SCHEMBL8337458 0.83 UTS2R (0.68) UTS2R
SCHEMBL6677188 0.83 UTS2R (0.63) UTS2R
SCHEMBL6672599 0.82 UTS2R (0.66) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043369-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed