Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.63 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23011772 | 0.86 | KCNK3 (0.82) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL12793496 | 0.83 | MEN1 (0.77) | SMN1; SMN2MAPTKMT2AMEN1NPC1 | |
| SCHEMBL27179645 | 0.80 | MAPT (0.77) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL30927052 | 0.80 | MAPT (0.77) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL27179632 | 0.79 | MAPT (0.76) | SMN1; SMN2MAPTKMT2AMEN1NPC1 | |
| SCHEMBL30926895 | 0.79 | MEN1 (0.60) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL20063247 | 0.79 | MEN1 (0.60) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL30926707 | 0.79 | MAPT (0.76) | SMN1; SMN2MAPTKMT2AMEN1NPC1 | |
| SCHEMBL2529744 | 0.79 | LMNA (0.69) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A | |
| SCHEMBL12496157 | 0.79 | KCNK3 (0.82) | SMN1; SMN2MAPTKCNK3KCNK9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-09-27 | — | — | US | claimed |
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2012-06-14 | — | — | US | disclosed |
| US-8143269-B2 | Inhibitors of store operated calcium release | CALCIMEDICA, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143269-B2 | Inhibitors of store operated calcium release | CALCIMEDICA, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100087415-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100087415-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA, INC. (US) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149673-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | ORAI1, SARAF, RYR2 | SMN1; SMN2 608/4885MAPT 1453/4885KCNK3 420/4885 |
| US-20100087415-A1 | INHIBITORS OF STORE OPERATED CALCIUM RELEASE | ORAI1, SARAF, RYR2 | SMN1; SMN2 608/4885MAPT 1453/4885KCNK3 420/4885 |
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | HSPA5, HSP90B1, ATP2A1 | SMN1; SMN2 2319/4885MAPT 2245/4885KCNK3 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.