Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.66 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341726 | 0.89 | ESR1 (0.74) | ESR1ESR2MAOB | |
| SCHEMBL8341280 | 0.86 | ESR1 (0.86) | ESR1ESR2MAOB | |
| SCHEMBL8341396 | 0.86 | ESR1 (0.76) | ESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL11599689 | 0.82 | ESR1 (0.71) | ESR1ESR2 | |
| SCHEMBL21260801 | 0.81 | ESR1 (0.78) | ESR1ESR2MAOB | |
| SCHEMBL15660907 | 0.80 | ESR1 (1.00) | ESR1ESR2MAOB | |
| SCHEMBL11600001 | 0.79 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL8338171 | 0.79 | ESR1 (0.63) | ESR1MAOBHSD17B1HSD17B2 | |
| SCHEMBL8337732 | 0.79 | ESR1 (0.77) | ESR1ESR2 | |
| SCHEMBL8340581 | 0.77 | ESR1 (0.74) | ESR1ESR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908859-A | ESPECIALLY HYPERCHOLESTEROLEMIA | ELI LILLY AND COMPANY (US) | 1999-06-01 | — | — | US | disclosed |
| EP-0897918-A1 | Benzothiophene derivatives and their use as pharmaceutically active agents | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |