Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341280 | 0.90 | ESR1 (0.86) | ESR1ESR2MAOB | |
| SCHEMBL15660907 | 0.85 | ESR1 (1.00) | ESR1ESR2MAOB | |
| SCHEMBL21260801 | 0.85 | ESR1 (0.78) | ESR1ESR2MAOB | |
| SCHEMBL8630381 | 0.84 | ESR1 (0.80) | ESR1ESR2LMNA | |
| SCHEMBL8341726 | 0.82 | ESR1 (0.74) | ESR1ESR2MAOB | |
| SCHEMBL8340754 | 0.82 | ESR1 (0.61) | ESR1ESR2MAOB | |
| SCHEMBL20748207 | 0.81 | ESR1 (0.63) | ESR1ESR2 | |
| SCHEMBL20748115 | 0.80 | ESR1 (0.62) | ESR1ESR2 | |
| SCHEMBL20747938 | 0.80 | ESR1 (0.73) | ESR1ESR2LMNA | |
| SCHEMBL20748058 | 0.79 | ESR1 (0.67) | ESR1ESR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908859-A | ESPECIALLY HYPERCHOLESTEROLEMIA | ELI LILLY AND COMPANY (US) | 1999-06-01 | — | — | US | disclosed |
| EP-0897918-A1 | Benzothiophene derivatives and their use as pharmaceutically active agents | ELI LILLY AND COMPANY (US) | 1999-02-24 | — | — | EP | disclosed |