Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 11/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191232 | 1.00 | P2RX3 (0.45) | P2RX3PTPN1PRMT5WDR77MCL1 | |
| SCHEMBL3179833 | 1.00 | P2RX3 (0.45) | P2RX3PTPN1PRMT5WDR77MCL1 | |
| SCHEMBL3183919 | 0.90 | PRMT5 (0.41) | P2RX3PRMT5WDR77MCL1NR1H2 | |
| SCHEMBL8342839 | 0.90 | PRMT5 (0.41) | P2RX3PRMT5WDR77MCL1NR1H2 | |
| SCHEMBL13481581 | 0.87 | PRMT5 (0.39) | P2RX3PTPN1PRMT5WDR77MCL1 | |
| SCHEMBL13481650 | 0.84 | PRMT5 (0.42) | PRMT5WDR77MCL1NR1H2HRH3 | |
| SCHEMBL30065361 | 0.81 | P2RX3 (0.45) | P2RX3PTPN1MCL1NR1H2NR1H3 | |
| SCHEMBL24740458 | 0.81 | P2RX3 (0.51) | P2RX3PTPN1MCL1NR1H2NR1H3 | |
| SCHEMBL2434896 | 0.80 | P2RX3 (0.50) | P2RX3PTPN1MCL1NR1H2NR1H3 | |
| SCHEMBL6846802 | 0.80 | P2RX3 (0.53) | P2RX3PTPN1MCL1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004039367-A1 | PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT | PFIZER LIMITED (GN) | 2004-05-13 | — | — | WO | disclosed |