Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335690 | 0.84 | MMP1 (0.36) | HTTKDM4ECRHBPCRHR2GAA | |
| SCHEMBL8340007 | 0.80 | TDP1 (0.49) | HTTKDM4ECRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL8335999 | 0.76 | TDP1 (0.51) | HTTKDM4ECRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL8336211 | 0.73 | HTT (0.42) | HTTKDM4EGAASMN1; SMN2CYP1A2 | |
| SCHEMBL8336596 | 0.72 | TDP1 (0.53) | HTTKDM4ECRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL8335861 | 0.71 | HTT (0.39) | HTTKDM4ECRHBPCRHR2GAA | |
| SCHEMBL8339547 | 0.69 | HPGD (0.42) | HTTKDM4ECRHBPCRHR2GAA | |
| SCHEMBL8340378 | 0.69 | HTT (0.44) | HTTKDM4EGAASMN1; SMN2TDP1 | |
| SCHEMBL8340529 | 0.67 | TDP1 (0.44) | HTTKDM4ECRHBPCRHR2GAA | |
| SCHEMBL8337202 | 0.65 | HPGD (0.39) | HTTKDM4ECRHBPCRHR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977177-A | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-11-02 | — | — | US | disclosed |
| US-5880155-A | TREATMENT OF CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-03-09 | — | — | US | disclosed |