Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10447095 | 0.98 | GRIN2B (0.53) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| SCHEMBL13357772 | 0.81 | GRIN2B (0.58) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| SCHEMBL5358231 | 0.81 | GRIN2B (0.58) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| SCHEMBL16980401 | 0.81 | RAB9A (0.53) | GRIN2BRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3834622 | 0.81 | GRIN2B (0.77) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10447002 | 0.80 | GRIN2B (0.57) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10447191 | 0.80 | POLB (0.62) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10446804 | 0.79 | GRIN2B (0.74) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| SCHEMBL5358070 | 0.78 | GRIN2B (0.58) | GRIN2BFYNSIGMAR1DRD2DRD3 | |
| SCHEMBL6833760 | 0.78 | GRIN2B (0.58) | GRIN2BFYNSIGMAR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001860-A | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0642498-A1 | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024458-A1 | NEW N-ARYL AND N-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1993-12-09 | — | — | WO | disclosed |