Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 9/20 | 0.42 |
| ▸ | HTR5A | P47898 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | SLC9A2 | Q9UBY0 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338997 | 0.81 | HTR5A (0.41) | SLC9A1HTR5AKDM4EL3MBTL1 | |
| SCHEMBL6082191 | 0.81 | BTK (0.36) | BTKKDM4EL3MBTL1PIK3R2PTGDR2 | |
| SCHEMBL8346528 | 0.80 | RORC (0.38) | SLC9A1HTR5AKDM4EL3MBTL1PIK3R2 | |
| SCHEMBL6081996 | 0.69 | PIK3R2 (0.43) | KDM4EL3MBTL1PIK3R2 | |
| SCHEMBL6082339 | 0.67 | CDK8 (0.36) | KDM4EL3MBTL1PIK3R2 | |
| SCHEMBL25205591 | 0.67 | PIK3R2 (0.38) | KDM4EL3MBTL1PIK3R2 | |
| SCHEMBL31095534 | 0.67 | PIK3R2 (0.38) | KDM4EL3MBTL1PIK3R2 | |
| SCHEMBL6083005 | 0.67 | CD38 (0.41) | — | |
| SCHEMBL6082100 | 0.67 | ADORA2A (0.36) | KDM4EL3MBTL1 | |
| SCHEMBL9907824 | 0.66 | HTR5A (0.56) | SLC9A1HTR5APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004007478-A2 | DERIVATIVES OF 3-GUANIDINOCARBONYL-1-HETEROARYL-PYRROLE, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-01-22 | — | — | WO | disclosed |