Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | HTR3A | P46098 | 8/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.66 |
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.65 |
| ▸ | HTR3B | O95264 | 7/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.65 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.65 |
| ▸ | CHRNG | P07510 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.65 |
| ▸ | CHRND | Q07001 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mdl-74156 SCHEMBL7281981 | 1.00 | KCNH2 (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Mdl-74156 SCHEMBL29386901 | 1.00 | KCNH2 (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Mdl-74156 SCHEMBL10512437 | 0.82 | HTR3A (0.68) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| SCHEMBL7289186 | 0.81 | HTR3A (0.71) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| SCHEMBL8323170 | 0.81 | KCNH2 (0.68) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| SCHEMBL8323177 | 0.81 | KCNH2 (0.68) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Dolasetron SCHEMBL24914047 | 0.80 | HTR3A (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Dolasetron SCHEMBL1819896 | 0.80 | HTR3A (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Dolasetron SCHEMBL20769824 | 0.80 | HTR3A (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B | |
| Dolasetron SCHEMBL1819898 | 0.80 | HTR3A (1.00) | KCNH2HTR3ASLC6A4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5910501-A | Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolozin-3(4H)-one and related compounds for treating cognitive disorders | MERRELL PHARMACEUTICALS INC. (US) | 1999-06-08 | — | — | US | claimed |
| EP-0494002-A2 | Use of certain esters of hexahydro-8-hydroxy-2, 6-methano-2H-quinolizin-3(4H)-one and related compounds for the preparation of medicaments for treating cognitive disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-08 | — | — | EP | claimed |
| US-5910501-A | Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolozin-3(4H)-one and related compounds for treating cognitive disorders | MERRELL PHARMACEUTICALS INC. (US) | 1999-06-08 | — | — | US | disclosed |
| EP-0494002-A2 | Use of certain esters of hexahydro-8-hydroxy-2, 6-methano-2H-quinolizin-3(4H)-one and related compounds for the preparation of medicaments for treating cognitive disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-08 | — | — | EP | disclosed |