Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.68 |
| ▸ | HTR3A | P46098 | 4/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.56 |
| ▸ | HTR3B | O95264 | 3/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323170 | 1.00 | KCNH2 (0.68) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8319559 | 0.95 | KCNH2 (0.62) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8319125 | 0.82 | HTR3A (0.52) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL8319129 | 0.82 | HTR3A (0.52) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| Mdl-74156 SCHEMBL29386901 | 0.81 | KCNH2 (1.00) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| Mdl-74156 SCHEMBL7281981 | 0.81 | KCNH2 (1.00) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| Mdl-74156 SCHEMBL8339181 | 0.81 | KCNH2 (1.00) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL13186222 | 0.80 | HTR3A (0.68) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9471661 | 0.80 | HTR3A (0.71) | KCNH2HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL13186221 | 0.79 | HTR3A (0.85) | KCNH2HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955470-A | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL PHARMACEUTICALS, INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0517984-A1 | Derivatives of amide analogs of certain methano bridged quinolizines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-16 | — | — | EP | disclosed |