Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.75 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8338023 | 0.87 | MMP12 (0.57) | MMP12EPHX2MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL8339549 | 0.85 | MMP12 (0.72) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL8341227 | 0.83 | MMP12 (0.77) | MMP12MAPK1MAPTSMN1; SMN2HDAC3 | |
| SCHEMBL6873364 | 0.82 | MMP12 (0.74) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL6880697 | 0.82 | MMP12 (0.78) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL8342537 | 0.81 | MMP12 (0.77) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL6874960 | 0.81 | MMP12 (0.77) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL6874687 | 0.80 | MMP12 (0.83) | MMP12EPHX2SMN1; SMN2RORCNPC1 | |
| SCHEMBL6873463 | 0.80 | MMP12 (0.71) | MMP12NR1H4EPHX2MAPK1RORC | |
| SCHEMBL6875476 | 0.80 | MMP12 (0.71) | MMP12NR1H4EPHX2MAPK1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018448-A1 | NOVEL THIOPHENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | WARNER-LAMBERT COMPANY LLC (US) | 2004-03-04 | — | — | WO | disclosed |