Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.78 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.54 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8342379 | 0.85 | MMP12 (0.57) | MMP12TRPV1MAPK1ALDH1A1MMP8 | |
| SCHEMBL6451834 | 0.85 | MMP12 (0.56) | MMP12TRPV1MAPK1MMP3MMP9 | |
| SCHEMBL6874960 | 0.83 | MMP12 (0.77) | MMP12RORCEPHX2NR1H4RXRA | |
| SCHEMBL8342537 | 0.83 | MMP12 (0.77) | MMP12RORCEPHX2NR1H4RXRA | |
| SCHEMBL8341227 | 0.83 | MMP12 (0.77) | MMP12MAPK1ALDH1A1MMP8MMP13 | |
| SCHEMBL8339276 | 0.82 | MMP12 (0.75) | MMP12TRPV1RORCEPHX2NR1H4 | |
| SCHEMBL6874687 | 0.82 | MMP12 (0.83) | MMP12RORCEPHX2FFAR1LMNA | |
| SCHEMBL6461928 | 0.81 | MMP12 (1.00) | MMP12RORCEPHX2NR1H4FFAR1 | |
| SCHEMBL8339549 | 0.80 | MMP12 (0.72) | MMP12RORCEPHX2NR1H4RXRA | |
| SCHEMBL6456507 | 0.80 | MMP12 (0.72) | MMP12RORCEPHX2NR1H4RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | WARNER-LAMBERT COMPANY LLC | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072871-A1 | Novel thiophene derivatives, their process of preparation and the pharmaceutical compositions which comprise them | MMP11, MMP13, CBR1 | MMP12 7/4885TRPV1 2306/4885RORC 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.