Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.81 |
| ▸ | TSHR | P16473 | 5/20 | 0.81 |
| ▸ | DPP4 | P27487 | 3/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | RECQL | P46063 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL555986 | 0.90 | DPP4 (0.92) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL5323627 | 0.90 | DPP4 (1.00) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL4074251 | 0.88 | DPP4 (0.94) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL13939505 | 0.87 | NPSR1 (0.76) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL4669794 | 0.87 | DPP4 (1.00) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL554515 | 0.87 | DPP4 (1.00) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL13939659 | 0.87 | ALDH1A1 (0.80) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL4667712 | 0.85 | DPP4 (0.90) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL4667057 | 0.85 | DPP4 (0.90) | ALDH1A1NPSR1TSHRDPP4MAPK1 | |
| SCHEMBL12604413 | 0.85 | DPP4 (0.81) | ALDH1A1NPSR1TSHRDPP4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004033455-A2 | HEMISUCCINATE SALTS OF HETEROCYCLIC DPP-IV INHIBITORS | NOVO NORDISK A/S (DK) | 2004-04-22 | — | — | WO | disclosed |
| WO-2003057200-A2 | COMPOSITIONS COMPRISING INHIBITORS OF DPP-IV AND NEP ENZYMES FOR THE TREATMENT OF DIABETES | NOVO NORDISK A/S (DK) | 2003-07-17 | — | — | WO | disclosed |