SCHEMBL8339645

SCHEMBL8339645

Cc1cc(S(=O)(=O)Nc2ccc(C(F)(F)F)c(O[C@@H]3CCN(C)C3)c2)c(C)cc1Cl

nearest known ligand 0.68

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 17/20 0.68
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
LMNA P02545 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5835533 0.88 UTS2R (0.71) UTS2R
SCHEMBL5835543 0.88 UTS2R (0.71) UTS2R
SCHEMBL8342516 0.87 UTS2R (0.68) UTS2R
SCHEMBL8337844 0.87 UTS2R (0.70) UTS2RMEN1KMT2ALMNA
SCHEMBL8339797 0.86 UTS2R (0.71) UTS2R
SCHEMBL5835622 0.86 UTS2R (0.69) UTS2R
SCHEMBL5835628 0.86 UTS2R (0.69) UTS2R
SCHEMBL8339351 0.86 UTS2R (0.66) UTS2R
SCHEMBL5839583 0.85 UTS2R (0.82) UTS2R
SCHEMBL5835294 0.85 UTS2R (0.68) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed