SCHEMBL8339797

SCHEMBL8339797

Cc1cc(Br)ccc1S(=O)(=O)Nc1ccc(C(F)(F)F)c(O[C@@H]2CCN(C)C2)c1

nearest known ligand 0.71

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.71
GHSR Q92847 1/20 0.48
BRD4 O60885 1/20 0.43
BRD1 O95696 1/20 0.43
BRPF1 P55201 1/20 0.43
BRPF3 Q9ULD4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8340925 0.89 UTS2R (0.69) UTS2R
SCHEMBL5835130 0.89 UTS2R (0.68) UTS2R
SCHEMBL5835135 0.89 UTS2R (0.68) UTS2R
SCHEMBL5835495 0.87 UTS2R (0.70) UTS2RGHSRBRD4BRD1BRPF1
SCHEMBL5835494 0.87 UTS2R (0.70) UTS2RGHSRBRD4BRD1BRPF1
SCHEMBL6820879 0.87 UTS2R (0.70) UTS2R
SCHEMBL8339810 0.87 UTS2R (0.70) UTS2R
SCHEMBL8339645 0.86 UTS2R (0.68) UTS2R
SCHEMBL8342516 0.86 UTS2R (0.68) UTS2R
SCHEMBL8337844 0.86 UTS2R (0.70) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043366-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed