Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8334676 | 0.86 | MTNR1A (0.51) | ALOX5TDP1METLMNAMTNR1A | |
| SCHEMBL8336624 | 0.79 | MEN1 (0.42) | CISD1MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL6583757 | 0.77 | TNKS2 (0.43) | TNKS2AKR1B1ALOX5METTUBB4A | |
| SCHEMBL8340297 | 0.75 | PTPN1 (0.48) | TNKS2IGF1RAKR1B1ALOX5TDP1 | |
| SCHEMBL8888904 | 0.75 | ESR1 (0.38) | IGF1RLMNAALDH1A1 | |
| SCHEMBL8887977 | 0.71 | ESR1 (0.40) | IGF1RLMNAALDH1A1 | |
| SCHEMBL8890490 | 0.70 | ESR1 (0.42) | IGF1RLMNAALDH1A1 | |
| SCHEMBL6583749 | 0.69 | PPARG (0.47) | TNKS2IGF1RAKR1B1ALOX5MET | |
| SCHEMBL6964722 | 0.69 | POLB (0.41) | LMNAPOLB | |
| SCHEMBL16372690 | 0.68 | AKR1B1 (0.71) | TNKS2AKR1B1ALOX5METLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965589-A | AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0783496-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-16 | — | — | EP | disclosed |
| WO-1997000249-A1 | HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-03 | — | — | WO | disclosed |
| WO-1996005186-A1 | THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |