SCHEMBL8340562

SCHEMBL8340562

COc1ccc(C(=O)c2sc3cc(OC)ccc3c2-c2ccccc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.55
CNR2 P34972 2/20 0.53
CNR1 P21554 1/20 0.53
ESR1 P03372 5/20 0.52
ALDH1A1 P00352 3/20 0.51
MAPK1 P28482 2/20 0.51
MEN1 O00255 1/20 0.51
MAPT P10636 1/20 0.51
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ADORA1 P30542 4/20 0.50
ADORA3 P0DMS8 3/20 0.49
HTT P42858 2/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
HPGD P15428 1/20 0.49
CYP2C19 P33261 1/20 0.49
SCD O00767 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8341825 0.96 ESR1 (0.50) MAOBCNR2CNR1ESR1ALDH1A1
SCHEMBL11598733 0.93 ADORA1 (0.53) MAOBCNR2CNR1ESR1ALDH1A1
SCHEMBL8340731 0.90 MAPT (0.49) MAOBESR1MAPK1MEN1MAPT
SCHEMBL11599683 0.90 MAOB (0.59) MAOBCNR2CNR1ALDH1A1MAPK1
SCHEMBL8335288 0.90 MAOB (0.69) MAOBCNR2CNR1ALDH1A1MAPK1
SCHEMBL8341675 0.87 ESR1 (0.43) MAOBCNR2CNR1ESR1ALDH1A1
SCHEMBL11602513 0.86 MAOB (0.51) MAOBESR1ALDH1A1MAPK1MEN1
SCHEMBL11599719 0.85 ESR1 (0.47) MAOBCNR2CNR1ESR1ALDH1A1
SCHEMBL8341185 0.84 RORB (0.47) ESR1MAPK1MAPTHTTTUBB4A
SCHEMBL11547494 0.83 CNR2 (0.76) CNR2CNR1ESR1L3MBTL1TUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5908859-A ESPECIALLY HYPERCHOLESTEROLEMIA ELI LILLY AND COMPANY (US) 1999-06-01 US disclosed
EP-0897918-A1 Benzothiophene derivatives and their use as pharmaceutically active agents ELI LILLY AND COMPANY (US) 1999-02-24 EP disclosed
US-4075227-A NONSTEROIDAL ELI LILLY AND COMPANY (US) 1978-02-21 US disclosed