Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12510434 | 0.82 | MEN1 (0.49) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL29955467 | 0.81 | ENPP2 (0.43) | KDM4CMEN1KMT2ALIPEENPP2 | |
| SCHEMBL1683258 | 0.81 | ENPP2 (0.43) | KDM4CMEN1KMT2ALIPEENPP2 | |
| SCHEMBL12634797 | 0.81 | ALDH1A1 (0.55) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL772517 | 0.81 | KDM4C (0.50) | KDM4CMEN1KMT2ALIPEL3MBTL1 | |
| SCHEMBL12634794 | 0.81 | KDM4C (0.47) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL1345450 | 0.80 | KDM4C (0.49) | KDM4CMEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL871773 | 0.79 | KMT2A (0.55) | KDM4CMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8295420 | 0.78 | ALDH1A1 (0.52) | KDM4CMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL772662 | 0.78 | KDM4C (0.47) | KDM4CMEN1KMT2AL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866568-A | ENDOTHELIN RECEPTOR ANTAGONIST ACTIVITY | ZENECA LIMITED (GB) | 1999-02-02 | — | — | US | disclosed |